11,629/13,609 deaths (85.5%) did not occur close to a hospital admission, and the remaining 656/13,609 deaths (4.8%) occurred in hospital following admission due to drug poisoning. The risk of opioid-related death increased in this period, with odds ratios of 4.39 (95% CI 3.75 to 5.14 p < 0.001) on days 1 to 2 after discharge and 2.09 (95% CI 1.92 to 2.28 p < 0.001) on days 3 to 14. 1,088/13,609 deaths (8.0%) occurred in the 14 days after discharge. The risk during hospital admissions was similar or lower than periods neither admitted to the hospital nor recently discharged, with odds ratios 1.03 (95% CI 0.87 to 1.21 p = 0.75) for the first 14 days of an admission and 0.41 (95% CI 0.30 to 0.56 p < 0.001) for days 15 onwards. A total of 236/13,609 deaths (1.7%) occurred following drug use while admitted to the hospital. We estimated the association between hospital admission and opioid-related death using conditional logistic regression, with a reference category of time neither admitted to the hospital nor within 14 days of discharge. We used data from the national Hospital Episode Statistics database to determine the time proximity of deaths and control days to hospital admissions. For each death, we sampled 5 control days from the period 730 to 28 days before death. Our study included 13,609 deaths between Januand Decemamong individuals aged 18 to 64.
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